My wife travels, on average, early every Monday to late every Thursday; most weeks of the year. It is not easy on us, but certainly not the most difficult thing to imagine either.
I am not sure about advice I can give; I am not sure that we do it all very well. The best part of the scenario is that she loves her job, does good work and I am happy to support her pursuit of happiness.
We only get to talk about 1/2 hour everyday and honesty do not skype or webchat all that often. It is a nice technology but cumbersome to work into her busy schedule. We plan many things both near term and far and try to stick to those plans fairly tightly.
I, being unemployed and disabled, have taken the role of house husband and do all that I can to make sure that all things run smoothly so that she has a nice and peaceful home to return to. A few hobbies and a good pet keep me occupied and happy enough in her absence. I get lonely at times but we tend to make up for it with personal agreements about our own space and an active lifestyle while we are together.
For her, I believe that having the best of all minor conveniences does help her handle the travel. Top notch luggage, high quality wardrobe, luxurious transport, eating well and often, attending social or cultural events and facilities to exercise regularly.
She is very well compensated for her work and it absolutely makes everything work better for us, no doubt. If possible, I advise that you always use all of the support structures that her employer can offer and any advantage you can gain through travel services, mentoring structures, credit card points or travel rewards, etc.. I find it amusing that the more money you make, the more free stuff you get.
Transitioning into this lifestyle was difficult at first in the sense that we both had to work out a system to give each other freedom and still rely on each other to support the other. Honestly, the amount of money we have now was almost unimaginable to us before and that took a whole other set of adjustments, too. If this move is providing well for you or if it presents a hardship, either way you will have to adjust your lifestyle accordingly and in agreement. Open and honest dialogue is of paramount importance.
If she is happy, then find strength in that fact and work hard to support her happiness. Reread that last sentence again, it is important. Do not lose yourself in her pursuits, but work to realign your interests instead of trying to hold onto old positions. We like that life is an adventurous, roller coaster ride that can be fun and scary at the same time.
I remind myself frequently that the absolute best strategy to save yourself from drowning is to simply become the ocean.