First, make sure your battery is charging. On a low optioned older vehicle with a healthy battery, you can run for quite a while without a charging battery. You need around 13.5 volts across the battery at 1500 RPM and all high draw accessories on (high beams, blower on high, A/C clutch, etc)
If your alternator is good and the battery is charging, follow the steps to diagnose a parasitic drain.
As stated, disconnect the negative lead from the battery, then hook an ammeter up between the negative post on the battery and the negative lead you just disconnected.
You want AT MOST 50 milliamps of draw with all accessories off.
Now go around pulling fuses once at a time till you find the circuit that is causing the drain. Then you should be able to use a schematic to find out what is run off that circuit and narrow it down from there.
PROTIP: Put a 5 amp fuse in line with the test leads on the meter. The internal fuses in multimeters are typically expensive and somewhat tough to come by compared to automotive blade fuses. Fluke is really proud of their fuses.
PROTIP: The above procedures won't work on modern GM vehicles that use a CAN or similar. They can stay awake for approx 45 minutes and have a pretty big draw during that time that can lead to false positives. You need a Tech II to put the vehicle to sleep before you can start diagnosis.
PROTIP: If you find that you do not have a huge battery draw (50-70 milliamps) and your battery is charging well and you do not have a 150 amp meter to check between the battery and the alternator, check all the connections. Make sure they are all clean, tight, and secure. Measure the resistance of all the battery cables and replace the ones that have any significant resistance (more than an ohm or 2). You should disconnect the battery cables from the load before testing resistance on them.
PROTIP: If you use an autoranging multimeter, make sure you note the range when taking your readings. I can't tell you the amount of times something has been misdiagnosed because of an autoranging multimeter being smarter than the tech doing the work.
PROTIP: A poor man's test for bad connections is to take a pair of jumper cables and go from the negative on the battery to a good engine connection and see if your situation improves. You can do the same from the positive on the battery to your power distribution area, thich is a major pain on an older GM because its on the starter.
I had a similar situation with one of my eclipses that was drawing 0.12 amps with the key off. A bad factory amp was the culprit. I swapped it out and my battery life greatly improved.