I've done the pop-up, the skoolie, 5th wheel, slide-in truck camper, and a smallish class A.
If you are going to live in it, get the biggest box with slides you can afford and tow it gingerly wherever you are headed. The big ones don't tow very well. Frequently, not only is the truck overloaded, the TT chassis is as well. A google search will show lots of 30+ foot boxes on their side in a ditch not far from a 1/2 ton or larger truck. Be careful towing, keep the speeds reasonable and it can be done safely. Keep in mind that unless your wife is driving another car, you will be stuck driving a full-size truck everywhere.
This rig drove reasonably well and got 6 mpg at 70. The truck is a 96 Ford F350, the TT is a 97 Jayco. Total weight was just shy of 20k pounds. With 2 slides it's not a bad place to live. This TT has a little over 100k miles on it, most of it behind my father's Dodge 2500. The diesel towed it better than the 460 Ford. The Dodge also got 9-10 mpg instead of 6-7.
If you are going to travel in it, get a Class A and a toad you can enjoy. When buying one, much like the TT and truck you don't want the chassis maxed out. GVWR on my F53 is 18k pounds. With everything loaded it tips the scales at 14k-15k. The GCWR is 24k pounds so when I hook the XJ to the back, I'm still well under the chassis weight. It drives very well. I can set the cruise at 72 and run with traffic with one hand on the wheel. Total weight of this rig is also right at 20k pounds.
It has the advantage of being able to tow whatever I feel like driving when I get to my destination. Sometimes that's the XJ, sometimes it's a race car on a trailer. This one is a 1996 Ford F53 chassis with a 31' Tiffin box on it. Tiffin is one of the better motorhome builders. My only real complaint is the shower was built for someone half my size. The total cost for this rig, including the XJ was about $8500.
Another thing you might consider is power and rental costs at your destination. Most seasonal sites have metered power. TTs and motor homes aren't very efficient compared to a house. The propane furnaces can suck down a lot of gas in a month's time and the A/C units can use a good bit of power as well. You can offset that by following the weather. North in the summer and south in the winter.
Sites can run $300-$700 a month with metered power, plus another couple of hundred for power or water. Sites without metered power tend to be pretty expensive. Decent campgrounds that you actually want to stay in can run $750-$1500 a month. Add to that the cost of buying a TT or motorhome and the expenses can get pretty high. Make sure your budget can take that hit.