EDIT: A picture's worth a thousand words! I was a little slow with my tome... Thanks, Matthew Kennedy!
As Duke notes, the spring doesn't care whether the car is pressing down or the wheel is pushing up. It only cares about the distance between its two mounting points.
The important term which Duke also first mentioned above is "wheel rate". The rate of the spring and the leverage ratio (and a very little math) give you wheel rate. One important thing that hasn't been mentioned above is that wheel rate is the spring rate multiplied by the *square* of the motion ratio.
To explain, a MacPherson strut is very close to 1:1, because the amount the spring is compressed is very close to the amount the wheel is moved. 1 squared is 1, so a spring rate of 300 lb/in gives you a wheel rate of 300 lb/in.
By comparison, an arm with the wheel at the end and the spring in the middle has a ratio of 1:2. There are *two* things that happen as a result of that change in leverage. One is that the wheel has leverage, so if the spring is compressed 1" at a seat force of 300 lb, the wheel would be seeing only 150 lb. The other thing that gets missed sometimes in these discussions is that because of that ratio, if we see that spring compressed 1", the wheel has moved 2". For 1" of wheel motion, the spring would only be compressed 0.5", have a seat load of 150 lb, and a wheel load of 75 lb. EDIT: Summary: The "squaring" of the motion ratio is because it has a compound effect, and so is effectively applied twice (or that's how I tend to think of it): Once because it gives the wheel leverage over the spring, and AGAIN because it reduces how far the spring moves compared to the wheel.
To put it in the terms of your example with the spring at 6" and the axle at 18", and picking an arbitrary spring rate of 100 lb/in just to have all the terms, out motion ratio is 1:3, so our wheel rate is 1:9 with the spring rate. So our 100 lb/in spring gives us a wheel rate of 100/9 or about 11.1 lb/in. If we stick another six inches between spring and wheel so that the spring is still 6" from the pivot but the axle is out at 24", our motion ratio is 1:4, our wheel rate becomes 100/16 or about , 6.25 lb/in; a LOT softer.
We haven't talked about dampers at all, but increasing leverage ratio also has a similar effect on dampers, excepting that the reason is that doubling the motion ratio halves the damper velocity relative to the wheel, while having the same reduced leverage. So same principle, only applied to a device (the damper) that cares about velocity instead of position.