Design issues that annoy the bejesus out of me:
Branding everything aimed at male consumers with all-caps block letters, graphics suggesting a rusted surface, faux tribal tattoo motifs, skulls, barbed wire, etc. I do not need a beer, deodorant, multivitamin, boot socks, etc., to make me feel as though I am breaking an unjustly convicted buddy out of prison so that we can compete in an underground MMA fight and use the proceeds to build the world's fastest armed airboat that also runs on rattlesnake venom.
Conversely, packaging everything aimed at women in a vaguely hourglass or almond-shaped vessel, branding it with delicate all-lower-case fonts, and worst of all, slathering it with flirty, coy, and/or whimsical copy. Stealing a little of Mrs Monohue's shampoo is undignified enough already without that patronizing nonsense.
Trucks and SUVs with grilles and hoods designed expressly to intimidate, marketed toward people who generally don't need any help with that.
Convertible versions of bloated, wedge-shaped coupes with aggressively sloped beltlines, resulting in a car that looks like an overstuffed high-heeled shoe, with a deck lid that is almost as high as the header rail.
Vaporwave stuff that all looks the same, yet somehow looks nothing at all like the old stuff it's trying to imitate.
Multi-color titles wherein some letters use a color too close to that of the background, so that the sign reads "YA D ALE" rather than "YARD SALE".
Boastfulness in graphics, slogans, ad copy, and probably anything else.
A stock photo of a smiling woman wearing a headset reminding me that I can, if necessary, telephone AA American Pest Control and make an appointment.
A photo of one or more stern-looking people standing at a 3/4 angle to the camera with arms folded to indicate that they are utterly confident in their ability to clear clogged drains, repair a mangled Grand Caravan, restore electrical power following a storm, or defend me against a DUI charge.
YouTube Face.