For other considering a slide in here are couple things learned while growing up and our family having a slide-in.
1) You can like a nice set of sawhorses out of 2x6s that provide a stable support base when it isn't in the bed of the truck. Lowering it onto the sawhorses but not taking all the weight off the jacks provide plenty of stability to work on, clean, and pack for trips without having it on the truck.
2) If staying anywhere for an extended period of time it is helpful to have a second vehicle to go exploring. It's a pain to have to break camp to go to the supermarket or go exploring.
3) Good mirrors are critical, even more than with a trailer. You can't look over your shoulder to check before changing lanes. Intersections that are not at 90 degrees (y type) require planning to ensure you stop at an angle where you can see traffic.
4) once you get used to it, it's no worse to drive on a regular basis than a crew cab pickup, just watch the swing on the overhangs.